9. Green Goblin
It would have been impossible to mention Spider-Man and then leave the Green Goblin off the list, right? The two go together like Thelma and Louise if Thelma and Louise were the greatest arch-nemeses known to man.
There have been several aliases for this character over the years. The Green Goblin is one of those that different people have taken up, but the first is by far the greatest and most well-known. Norman Osborn was developed by Stan Lee and Steve Ditko as the archnemesis of the Amazing Spider-Man.
This is a character that could be viewed in a comical way. He’s Halloween-inspired, including the use of Jack-O’-Lanterns and ghosts. He’s the equivalent of Batman’s Joker, completely unhinged and dangerous. There is nothing that his guy would never do and that’s what makes him so formidable.
Despite being unhinged, he’s also smart with plenty of gadgets at his disposal. He doesn’t need superpowers to be the world’s greatest villain and he proves that technology can be the worst thing ever in the world if it lands in the hands of the wrong person.
This is certainly another villain that started with an idea from Lee and was developed further with the help of Ditko, proving the two to be masterminds together. Lee wanted a creature that rose from an Egyptian sarcophagus, but Ditko turned this mythical monster into a real villain. There were more personal stories created from this, forming a bond between Spidey and the Goblin that nobody had ever seen before.