25. Madame Gao
We first meet Gao in Daredevil as one of the Hell’s Kitchen gang leaders, but she swiftly grows into something much more. Very quickly, we learn that the gang leaders are actually the founders of The Hand, a clandestine group of ninja who controlled New York’s criminal underground. Gao ran the heroin trade and used it to gain influence throughout the city.
The Hand seek to gain the power of immortality and it seems that Gao has gained this power. During her early life in K’un L’un, Gao teamed up with the other four leaders of the Hand to gain this power and succeeded. They discovered that the key to immortality was in the bones of dragons and used this to gain power across the world.
Eventually, Gao was banished from K’un L’un along with the other leaders and found her way to New York.
Not only does she play a part in the first two seasons of Daredevil, but she also features in Iron Fist and goes on to have an important role in The Defenders. It’s for this reason that Gao makes the list. After being a thorn in the side of all four of the Marvel Netflix series’ main characters, she eventually meets her end during the battle for Midland Circle.